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| NIPOFABs – Smerom k nanotechnológiám využívajúcim bioaktívne častice/molekuly v boji proti mikrobiálnym biofilmom | |
| Towards nanotechnologies using bioactive particles/molecules in the fight against microbial biofilms | |
| Program: | SRDA |
| Project leader: | Ing. Pálková Helena, PhD. |
| Annotation: | The topic of submitted project reflects current scientific challenges using the strategy of an interdisciplinary approach in tackling the highly urgent issues of microbial biofilms. It is focused on the fields of basic and molecular microbiology in association with study of the prevention or eradication of microbial biofilms using novel hybrid materials. In the project, biological research is closely linked to various approaches in the field of the nanomaterial chemistry. The main subject of the study will cover multispecies biofilms, not only composed of bacteria but also of yeasts and their mutual combinations, which reflects their significance in biofilm-associated infections. The tested microorganisms will include Staphylococcus aureus, enterococci, Escherichia coli, and representatives of yeasts of the genus Candida. The formation of biofilms, interspecies interactions, including the role of quorum sensing molecules in these processes, as well as the effectiveness of bioactive particles/molecules in the prevention and eradication of biofilms, including the phenomenon of multidrug resistance, will be studied in detail by modern microbiological methods. Hybrid materials based on inorganic layered nanoparticles in the role of carriers of bioactive organic molecules, in particular photosensitizers, will be used as active materials. Functionalized nanoparticles will be used to modify the surfaces of selected types of polymers often used in medical practice. The aim will be to prepare new or improved materials to achieve maximal antimicrobial effectiveness. The results of the project could bring new knowledge in the topic of microbial biofilms, but also in the preparation of antimicrobial hybrid systems applicable in various fields of nanomedicine. |
| Duration: | 1.7.2022 – 30.6.2026 |
| Potenciál vrstevnatých aluminosilikátov ako excelentných nosičov polykatiónov: dizajnovanie nových kompozitných nanomateriálov | |
| Potential of layered aluminosilicates as excellent guests to accommodate polymeric cations: design of new composite materials | |
| Program: | VEGA |
| Project leader: | Ing. Pálková Helena, PhD. |
| Annotation: | The project is aimed at the preparation of composite materials based on layered aluminosilicates as suitablecarriers for different types of organic polycations, possessing properties interesting for various applications. Thevariability in the chemical composition of the selected layered materials in connection with the diversity of themolecular structures and properties of polymeric cations and copolymers opens up wide opportunities towardsthe preparation of well-defined systems. Careful selection of the inorganic carries and polycations is an essentialstep to achieve their mutual compatibility resulting not only in preserving but primarily in improving the keyproperties of the prepared composites. Therefore, the synthesis conditions (e.g. pH) and the addition of anothercomponent to the systems (fluorescent dyes, metal nanoparticles) will be evaluated. The cytotoxicity test topredict biocompatibility of the materials, photoactivity, catalytic and adsorption efficiency will be assessed as well. |
| Duration: | 1.1.2021 – 31.12.2024 |
| BioPolSil – Bionanokompozitné materiály na báze vrstevnatých silikátov | |
| Bionanocomposites based on organic polycations and layered silicates | |
| Program: | SRDA |
| Project leader: | RNDr. Madejová Jana, DrSc. |
| Annotation: | The basic research project deals with the preparation and complex characterisation of the structurally unique typesof hybrid materials consisting of clay minerals from smectite group and new synthesized poly(ethylene imine)based polycations. Polymerization of oxazolines opens a wide range of possibilities for the preparation of welldefinedpolycations with precisely designed molecular architectures and properties in order to prepare suitableintercalating agents for clay minerals modifications. The aim is to provide nanocomposites with interestingbiocompatible or biodegradable properties. To achieve this aim a detailed investigation of the effect of variousfactors on the molecular characteristics of poly(ethylene imine) based polycations and consequently on theirbehavior upon smectites interlayers intercalation has to be performed using wide range of different experimentaltechnique (e.g., XRD, XPS, MAS NMR, and IR spectroscopies) but also by means of DFT method in the solidstate.Biocompatibility of prepared polycations and their smectite intercalates will be assed based on cell viability assayand cell morphology after direct contact with selected substances. Prepared polycationic-smectites will be furtherstudied due to their possible applications as new types of fillers for selected biodegradable polymers, drug-deliverysystems and as new composite materials with optical properties. Interdisciplinary project, as designed, providesunique platform for understanding the properties of the newly synthesized polycation-smectite composites. This approach can significantly contribute to the current level of knowledge in the fields of nanomaterials and has the potential for acquiring fundamentally new results. |
| Duration: | 1.7.2020 – 30.6.2024 |